Marco: Haha wo Tazunete Sanzenri(1999)

In the 19th century, Genoa (Italy), 9-year-old Marco must face separation from his mother Anna, who leaves for work in Argentina to escape heavy taxes and a deep economic depression. Remaining at home with his father-a doctor at the hospital for the poor-Marco cannot help but miss his mother. When Anna suddenly stops writing to them, Marco becomes anxious about her and decides to travel all the way to Argentina by himself. Marco sets out a long and arduous adventure of over 10,000 miles. All he carries with him is love, courage, friendship and a longing to see his mother again. The story will take you on an exciting journey across the Atlantic, the Andes, and the spiritual border as we watch Marco come of age.

(Source: AnimeNfo)