Otherworld Barbara(2003)

Tokio discovers a phantom island named Barbara. Then there’s a mysterious and missing geneticist, an eccentric clergyman, a grieving grandmother granted temporary youth, a psychologist killed by a freak tornado… Hagio offers a sci-fi explanation for these seemingly random paranormal elements, and makes it all matter with believable characters in complex and subtle relationships.

(Source: Fantagraphics)

Note: Winner of Japan's Science Fiction Grand Prize award in 2006.