Yajikita Gakuen Douchuuki(1982)

Yaji and Kita and their adventures parody two comedic figures from Japanese literature who wandered from town to town, encountering bad guys and generally making fools of themselves. In this iteration, they are two schoolgirls who wander from school to school, fighting the bad guys and generally saving the day. Rei Shinokita (Kita) is a butchy, serious blonde girl with a penchant for rescuing (and becoming the object of affection for) lovely young ladies, and Junko Yajima (Yaji) is a tall, lovely brunette girl with a impetuous nature and a habit of rescuing (and becoming the object of affection for) beautiful boys. In practically every arc of Yajikita, you can be sure of a few things – the yakuza will be involved, there will be much fighting, Yaji and Kita will be inutterably cool, the girl will fall in love with Kita and the boy with Yaji.

(Source: Okazu, edited)

Note: Yajikita Gakuen Douchuuki was initially serialized in Bonita from 1982 to 1991. It continued to be serialized in Mystery Bonita from December 6, 2003, to February 6, 2006. The first 22 volumes were published by Akita Shoten between 1983 and 1991; volumes 23 through 29 were published from 2004 to 2006.